Very few rooms are perfectly square. You need to see what differences there are in the dimensions and work out how to deal with them. Starting from a line centred on a doorway or the middle of the room, try laying a row of tiles on the floor in a dummy run so you can see where the cut tiles will occur. If you end up with tiny slivers move the middle row one way or the other so the cut tile is more substantial (2). For example, you can set the first row to straddle the centre line or to go either side of it.
To make sure the first row of tiles is perfectly straight, it is best to snap a line down the middle of the room with a piece of chalked string. Lay the string on pencil marks at either end and pull it tight then lift is slightly and let it ping onto the floor. This should leave a straight chalk line across the room (3).