Use spacers between tiles to establish grout lines. If the tiles are exactly the same size you can use tile-spacer crosses which you leave in place and grout over (5). If the tiles vary slightly in size you are better off using pegs or small pieces of timber which you can pull out when the adhesive dries. You may have to use your judgement in keeping the lines roughly equal if the tiles vary greatly in size.
On very large floor areas, you should incorporate a flexible silicone joint to allow for expansion. This is best done in line with a room opening or division so it appears as a natural division.
Wipe off all traces of adhesive from the tile faces as you go and rake out between the tiles before the adhesive sets.